1
0
0
News
Neutron study of glaucoma drugs offers clues about enzyme targets for...
www.ornl.gov
The hCA II active site is flanked by hydrophilic (violet) and hydrophobic (green) binding pockets that can be used to design specific drugs ...
Private Homepages
Growing HCA Crystals - The Road to the ESS - About - SINE2020 portal
sine2020.eu
SINE2020: Science and Innovation with Neutrons in Europe in 2020
Books & Literature
Carbonic Anhydrase: Its Inhibitors and Activators - Google Books
books.google.co.uk
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase...
Carbonic Anhydrases as Biocatalysts: From Theory to Medical and...
books.google.co.uk
However, one should stress that hCA II was the most investigated isoform for its interaction with inhibitors, and most kinetic, spectroscopic, and crystallographic ...
Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen...
books.google.co.uk
N OF3 N N N F3 N N N BnO O SO O SO O SO BnO S O O O hCA I : > hCA II : 2.5 hCA VA : 835 hCA IX : > O O O C hCA I : > hCA II : >
Drug Design of Zinc-Enzyme Inhibitors: Functional, ...books.google.co.uk › books
books.google.co.uk
This may explain the lower catalytic activity of isoform I, as well as the fact that it is usually 100 times less prone than hCA II to be inhibited by sulfonamides.
Related Documents
Protein compactness measured by fluorescence resonance energy...
www.diva-portal.org
This approach was developed in this study and was used to estimate the compactness of HCA II during heat denaturation and interaction with ...
Ultra-High Resolution X-Ray Diffraction from Crystals of the Kinetic ...msg.mbi.ufl.edu/papers duda2.pdf
msg.mbi.ufl.edu
that His 64 in human CA II (HCA II) functions as a proton shuttle in this manner ... HCA II in which His64 is replaced with Ala (H64A HCA II), has been shown to ...
Scientific Publications
Enzymatic CO2 capture by immobilized hCA II in an intensified...
www.sciencedirect.com
Ex vivo applications of human carbonic anhydrase II (hCA II) for its potential in CO2 capture technologies are emerging due to the formidably large hydration ...
The human carbonic anhydrase isoenzymes I and II (hCA I and II)...
pubmed.ncbi.nlm.nih.gov
Human CA isoenzymes I and II (hCA I and hCA II) are ubiquitous cytosolic isoforms. Acetylcholine esterase (AChE. EC ) is a hydrolase ...
Publications
IJMS | Free Full-Text | The Crystal Structure of a hCA VII Variant...
www.mdpi.com
In particular, in hCA II the presence of a network of well-ordered water molecules, connecting the Zn2+-bound solvent molecule to His64 (see ...
Carbonic anhydrase isoenzymes II and I are present in the zona...
link.springer.com
Both HCA II and. I were located in the zona glomerulosa cells, although the staining for HCA I was faint. The cells of the zona fasciculata and the zona reticularis ...
5y2r - Proteopedia, life in 3D
proteopedia.org
Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3(-). Although hCA II has been ...
Synthesis and In Vitro Inhibition Effect of New...
www.hindawi.com
The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among all the synthesized compounds, 7e ( µM) was ...
Reports & Statements
Wikipedia: Carbonic anhydrase II - Wikipediaen.wikipedia.org › wiki › Carbonic_anhydrase_II
Carbonic anhydrase II (gene name CA2), is one of sixteen forms of human α carbonic hea: CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) ( HCA II) (E.C ) MUTANT WITH LEU 198 REPLACED BY ARG (L198R).
Miscellaneous
Human Carbonic Anhydrase II ( Hca II ) Words | Bartleby
www.bartleby.com
This proposal focuses on human carbonic anhydrase II (HCA II), this enzyme has a tertiary structure and 29 kD polypeptide, which is the most ...
1LGD: Crystal Structure Analysis of HCA II RCSB PDBwww.rcsb.org › structure
www.rcsb.org
Substitution of Pro for Thr199 in the active site of human carbonic anhydrase II ( HCA II)(1) reduces its catalytic efficiency about fold.
RCSB PDB - 5LMD: The crystal structure of hCA II in complex with a...
www.rcsb.org
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and...
Turn in assignment - HCA II - Persuasive Essay - Blue Valley...
bluevalleyk12.libguides.com
Blue Valley School District · Blue Valley Libraries · Blue Valley Southwest High School · HCA II - Persuasive Essay; Turn in assignment.
(IUCr) Active-site solvent replenishment observed during human...
journals.iucr.org
Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. Although hCA II has been ...
Apo-Human Carbonic Anhydrase II Revisited: Implications of ...figshare.com › articles › Apo_Human_Carbonic_Anhydrase_II_Revis...
figshare.com
Human carbonic anhydrase II (HCA II) is a monomeric zinc-containing metalloenzyme that catalyzes the hydration of CO2 to form bicarbonate ...
WikiGenes - CA2 - carbonic anhydrase II
www.wikigenes.org
... 6M) was one of the best hCA I and hCA II inhibitor in the series and exhibited very strong anticonvulsant properties in an MES test in mice [24]. Finally, the ...
BRENDA : carbonic anhydrase
www.brenda-enzymes.org
BRENDA - The Comprehensive Enzyme Information System
Carbonic anhydrase activators. The selective serotonin reuptake...
orca.cardiff.ac.uk
For hCA II, the best activators were phenylalanine and citalopram, and the weakest histamine and sertraline, whereas fluoxetine showed an ...
Human carbonic anhydrase II : a novel scaffold for artificial...
edoc.unibas.ch
The interest in hCA II is motivated by the possibility to use this protein as a target, because it is overexpressed in various forms of cancers.
Hca email accountmatteopugi.com › hca-email-account
matteopugi.com
Oct 01, · Wild type HCA II, HCA IX Mimic (where part of the HCA II molecule has been adapted to mimic the active site of the HCA IX protein) and a HCA IX ...
Joint neutron crystallographic and NMR solution studies of Tyr...
www.osti.gov
The U.S. Department of Energy's Office of Scientific and Technical Information
High-resolution structural characterization of a heterogeneous...
pureportal.strath.ac.uk
The immobilized hCA II retained 71% of its specific enzymatic activity when compared to the free enzyme in solution. On the basis of the one- ...
Human carbonic anhydrase II as host protein for the creation of...
pubs.rsc.org
Critical cofactor – protein interactions revealed by the X-ray structure of [(η5-Cp*) Ir(pico 4)Cl] 9 ⊂ WT hCA II were genetically optimized to improve the catalytic ...
PRIME PubMed | Inhibition of mammalian carbonic anhydrase isoforms I,...
wwww.unboundmedicine.com
PubMed journal article: Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules. Download Prime PubMed App...
RCSB PDB - 3GZ0: Apo-human carbonic anhydrase II revisited:...
www.rcsb.org
Apo-human carbonic anhydrase II revisited: Implications of the loss of a metal in protein structure, stability and solvent network
New Dihydrothiazole Benzensulfonamides: Looking for Selectivity...
flore.unifi.it
All synthesized compounds, with the exception of compound EMAC10101k, preferentially inhibit off-target hCA II isoform. Within the series, compound ...
PDB-3v3g: Kinetic and structural studies of thermostabilized mutants...
pdbj.org
Structure visualization. Downloads & links. Title, Kinetic and structural studies of thermostabilized mutants of HCA II. Components, Carbonic anhydrase 2. Details.
Related search requests for Hca Ii
| Crystal Structure |
People Forename "Hca" (1) Name |
sorted by relevance / date